Kenzou Tenma , a brilliant Japanese brain surgeon working in Germany, saves the life of a small boy who has been shot in the head. Little does he know that doing so would destroy his entire career at the hospital and that his fiancé would leave him. When the hospital director and doctors of the hospital staff suddenly get murdered he gets a second chance, but also renders him as the main suspect to the murders. Life goes on for Tenma as he saves people at the hospital and he finds back to the joy of being a surgeon again.

Suddenly one day an injured thief gets brought to the hospital. After Tenma saves his life, he finds out that the thief is involved with the rising counts of serial murders happening in Germany. Suddenly Tenma is involved in it all when the little boy, who is now a young man, turns up and kills the thief in cold blood right in front of Tenma. Now Tenma must clear his name, find out more about the boy he saved in the past and reevaluate what the value of life is.